IMODULONMINER AND PYMODULON: SOFTWARE FOR UNSUPERVISED MINING OF GENE EXPRESSION COMPENDIA.

Public gene expression databases are a rapidly expanding resource of organism responses to diverse perturbations, presenting both an opportunity and a challenge for bioinformatics workflows to extract actionable knowledge of transcription regulatory network function.Here, we introduce a five-step computational pipeline, called iModulonMiner, to com

Varied environmental stress can affect cell growth and activity of the cellular catalyst.Traditional path of adaptive evolution generally takes a long time to achieve a tolerance phenotype, meanwhile, it is a challenge to dissect the underlying genetic mechanism.Here, using SCRaMbLE, a genome scale tool to generate random structural variations, a t